2019
Hasegawa M, Luong VH, Utsunomiya A, Chino T, Oyama N, Matsushita T, Obara T, Kuboi Y, Ishii N, Machinaga A, Ogasawara H, Ikeda W, Imai T. Anti-mouse CX3CL1 monoclonal antibody therapy in mouse models of systemic sclerosis. The Society for Investigative Dermatology. Chicago, Illinois, USA. May 8 (2019).
2018
Ikeda W, Hoshino-Negishi K, Nishioka E, Nakatani T, Kuboi Y, Ishii N, Yasuda N, Imai T. Anti-Fractalkine Monoclonal Antibody Dislodges Intravascular Monocytes Involved in Exacerbation of Synovial Inflammation in Collagen-Induced Arthritis Model. ACR/ARHP Annual Meeting. Chicago, Illinois, US. Oct 22 (2018).
Ishii N, Hoshino-Negishi K, Ohkuro M, Nakatani T, Ikeda W, Kuboi Y, Yasuda N, Imai T. Anti-Fractalkine Monoclonal Antibody Inhibits Joint Destruction through Suppression of Osteoclast Precursors Migration and Induces Synovial Cell Death in Collagen-Induced Arthritis Model. ACR/ARHP Annual Meeting. Chicago, Illinois, US. Oct 22 (2018).
Hoshino-Negishi K, Ohkuro M, Nakatani T, Kuboi Y, Nishimura M, Ida Y, Kakuta J, Hamaguchi A, Kumai M, Kamisako T, Sugiyama F, Ikeda W, Ishii N, Yasuda N, Imai T. Anti-Fractalkine Monoclonal Antibody Ameliorates Joint Destruction in Collagen-Induced Arthritis Model by Inhibiting Migration and Survival of Osteoclast Precursor Cells. ANZBMS Annual Scientific Meeting 2018. Queenstown, New Zealand. Sep 2 (2018).
Machinaga A, Hori Y, Shimizu K, Okahara K, Miyoshi M, Itoh T, Sasai K. Ascites-derived-PDX models effectively recapitulate the gemcitabine-resistance observed pancreatic cancer patients. Pancreatic Cancer: Advances in Science and Clinical Care (AACR Conference). Boston, Massachusetts, US. Sep 23 (2018).
Peng H, Chen J, Sawa Y, Estrada V, Kolber-Simonds D, Imai T, Koyama A, Neame S, Chen Q. Establishment of Bone Marrow Derived Macrophages for Drug Discovery in Alzheimer’s Disease. Gordon Research Conference. Castelldefels, Spain. Aug 5-10 (2018).
Ishii N, Negishi K, Okuro M, Ikeda W, Nakatani T, Kuboi Y, Yamauchi T, Yasuda N, Imai T. Anti-Fractalkine Monoclonal Antibody Ameliorates Joint Destruction in Collagen-Induced Arthritis Model by inhibition of Osteoclast Precursor Cell Survival and Migration. EULAR Annual Congress 2018. Amsterdam, Netherlands, Jun 14 (2018).
Vu H.L, Chino T, Oyama N, Hasegawa M, Obara T, Kuboi Y, Machinaga A, Ogasawara H, Ikeda W, Imai T, Ishii N. Blockade of CX3CL1-CX3CR1 pathway attenuates skin inflammation, fibrosis, and vascular injury in experimental mouse models of systemic sclerosis. International Investigative Dermatology (IID) 2018. Orlando, Florida, US. May 2018 (17).
2017
Luong VH, Chino Y, Oyama N, Obara T, Kuboi Y, Ishii N, Machinaga A, Ogasawara H, Ikeda W, Imai T, Hasegawa M. Anti-CX3CL1 monoclonal antibody: a promising therapy for systemic sclerosis. The 42nd Annual Meeting of the Japanese Society for Investigative Dermatology. Kochi, Japan. Dec 15 (2017).
Takegaki Y, Kadoi Y, Nishimura A, Miyoshi M, Akagi T, Sasai K, Hori Y. Oncogene transduced mouse pancreatic stem/progenitor cells show phenotypes similar to tumor-initiating cells. 40th Annual Meeting of the Molecular Biology Society of Japan. Kobe, Hyogo, Japan. Dec 6 (2017).
Kadoi Y, Shimizu K, Takegaki Y, Nishimura A, Miyoshi M, Akagi T, Sasai K, Hori Y. Establishment of novel gemcitabine-resistant mouse pancreatic cancer cell line. 40th Annual Meeting of the Molecular Biology Society of Japan. Kobe, Hyogo, Japan. Dec 6 (2017).
Kadoi Y, Simizu K, Takegaki Y, Nishimura A, Miyoshi M, Akagi T, Sasai K, Hori Y. Establishment of novel gemcitabine-resistant mouse pancreatic cancer cell line. 48th Annual Meeting of American Pancreatic Association. San Diego, California, USA. Nov 8 (2017).
Takegaki Y, Shimizu K , Kadoi Y, Nishimura A, Miyoshi M, Akagi T, Sasai K, Hori Y. Oncogene transduced mouse pancreatic stem/progenitor cells show phenotypes similar to tumor-initiating cells. 48th Annual Meeting of American Pancreatic Association. San Diego , California, USA. Nov 8 (2017).
Tanaka Y, Takeuchi T, Umehara H, Nanki T, Yasuda N, Tago F, Kawakubo M, Kitahara Y, Hojo S, Kawano T, Imai T. Safety, Pharmacokinetics, and Efficacy of E6011, an Anti-fractalkine Monoclonal Antibody, in a First-in-patient Phase 1/2 Study on Rheumatoid Arthritis: 52-week Results. 2017 ACR/ARHP Annual Meeting. San Diego, California, USA. Nov 6 (2017).
Kuboi Y, Hoshino-Negishi K, Okuro M, Ikeda W, Nakatani T, Ishii N, Yamauchi T, Yasuda N, Imai T. Anti-Fractakine Monoclonal Antibody Ameliorates Joint Destruction in Collagen-Induced Arthritis Model through Suppression of Osteoclast Precursor Cell Migration into Joint Tissue . 2017 ACR/ARHP Annual Meeting. San Diego, California , USA. Nov 5 (2017).
Sato H, Muraoka S, Kusunoki N, Masuoka S, Yamada S, Imai T, Kawai S, Nanki T. Stimulation with resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumtoid arthritis. 2017 ACR/ARHP Annual Meeting. San Diego, California, USA. Nov 3 (2017).
Luong VH, Chino Y, Oyama N, Hasegawa M, Obara T, Kuboi Y, Machinaga A, Ogasawara H, Ikeda W, Imai T. Anti-CX3CL1 mAb therapy suppresses the development of BLM-induced and growth factors-induced skin fibrosis in mic. The 5th Annual Meeting of the International Cytokine and Interferon Society. Kanazawa, Ishikawa, Japan. Nov 1 (2017).
Luong Vu Huy, Chino T, Oyama N, Obara T, Kuboi Y, Ishii N, Machinaga A, Ogasawara H, Ikeda W, Imai T, Hasegawa M. Anti-CX3CL1 monoclonal antibody therapy suppresses the development of bleomycin-induced and growth factors-induced skin fibrosis in mice. The 5th Annual Meeting of the International Cytokine and Interferon Socity. Kanazawa, Ishikawa, Japan. Oct 29 (2017).
Nishimura M, Kuboi Y, Muramoto K, Mizuno K, Ogasawara H, Yamauchi T, Yasuda N, Imai T. Fractalkine mediated locally accumulated CX3CR1+ macrophages recruit iNOS+ macrophages and neutrophils by production of MCP-1 chemokine to lead immune mediated hepatitis. AASLD (American Association For The Study of Liver Diseases) The LIVER MEETING® 2017. Washington DC, USA. Oct 20 (2017).
Ishii N, Negishi K, Ohkuro M, Nakatani T, Ikeda W, Kuboi Y, Yamauchi T, Yasuda N, Imai T. Anti-Fractalkine Monoclonal Antibody Inhibits Joint Destruction in the Collagen-Induced Arthritis Mice Model via Suppressing Migration of Osteoclast Precursor Cells into Joint Tissue. The 19th Asia Pacific League of Associations for Rheumatology Congress. Dubai, U.A.E. Oct 16 (2017).
Tanaka Y, Takeuchi T, Umehara H, Nanki T, Yasuda N, Tago F, Kitahara Y, Kawakubo M, Hojo S, Kawano T, Imai T. SAFETY, PHARMACOKINETICS AND EFFICACY OF E6011, AN ANTI-FRACTALKINE MONOCLONAL ANTIBODY, IN A FIRST-IN-PATIENT PHASE 1/2 STUDY IN RHEUMATOID ARTHRITIS; ADDTIONAL DATA OF 400 mg COHORT . EULAR Annual congress 2017. Madrid, Spain. Jun 17 (2017).
Negishi K, Okuro M, Nakatani T, Ikeda W, Kuboi Y, Ishii N, Yamauchi T, Yasuda N, Imai T. Therapeutic Treatment Of Anti-Fractalkine Monoclonal Antibody Inhibits Joint Destruction In Collagen-Induced Arthritis Model . EULAR Annual congress 2017. Madrid, Spain. Jun 15 (2017).
2016
Kawano T, Yasuda N, Imai T. Chemokine targeting therapeutic antibody originated from Japan: E6011. The 41st meeting of Eastem Branch of the Japan Society of Hepatology. Tokyo, Japan. Dec 8 (2016).
Vu H.L, Chino T, Oyama N, Hasegawa M, Kuboi Y, Obara T, Machinaga A, Ogasawara H, Ikeda W, Imai T. Anti-CX3CL1 monoclonal antibody: a promising therapy for systemic sclerosis. The 45th Annual Meeting of The Japanese Society for Immunology. Okinawa, Japan. Dec 5 (2016).
Hoshino K, Okuro M, Ikeda W, Nakatani T, Kuboi Y, Ishii N, Yamauchi T, Yasuda N, Imai T. Anti-Fractalkine Monoclonal Antibody Inhibits Cartilage Destruction and Bone Erosion in Collagen-Induced Arthritis Model. American College of Rheumatology Annual meeting 2016. Washington DC, USA. Nov 14 (2016).
Moriuchi A, Kataoka K, Oba F, Kanekiyo M, Kawano T, Takikawa Y, Ido A, Tsubouchi H. Inclusion criteria and endpoint in clinical study for acute liver failure. Japan Digestive Disease Week 2016. Kobe, Hyogo, Japan. Nov 3 (2016).
Motoi S, Shimizu A, Ido A, Tsubouchi H, Toyoda H, Obara T, Ota E, Arita Y, Hoshino K, Moriya K, Soejima M, Imai T, Kawano T. Recombinant human hepatocyte growth factor (rh-HGF) protects against acetaminophen induced liver injury. Japan Digestive Disease Week 2016. Kobe, Hyogo, Japan. Nov 3 (2016).
Sawa Y, Yamada T, Kakuta J, Nishioka E, Nakatani T, Ono Y, Imai T. Identification of a microglial marker and generation of anti-Slco2b1 monoclonal antibodies. Keystone Symposia. Colorado, USA. Jun 12 (2016).
Tanaka Y, Takeuchi T, Umehara H, Nanki T, Akama H, Yasuda N, Tago F, Kawakubo M, Hojo S, Kawano T, Imai T. SAFETY, PHARMACOKINETICS AND EFFICACY OF E6011, AN ANTI-FRACTALKINE MONOCLONAL ANTIBODY, IN A FIRST-IN-PATIENT PHASE 1/2 STUDY IN RHEUMATOID ARTHRITIS. The European League Against Rheumatism. London, United Kingdom. Jun 8 (2016).
Matsuoka K, Naganuma M, Matsui T, Arai M, Tanida S, Kitamura K, Horiki N, Iimuro M, Mitsuyama K, Saruta M, Matsumoto T, Nebiki H, Esaki M, Kinjo F, Oketani K, Hojo S, Akama H, Imai T, Tsubouchi H, Hibi T, Kanai T. Safety, Tolerability and Efficacy of E6011, Anti-Human Fractalkine Monoclonal Antibody, in the First-in-Patient Study for Crohn’s Disease. Digestive Disease Week 2016. San Diego, CA, USA. May 23 (2016).
Tabuchi H, Oketani K, Katsurabara T, Mori M, Muraishi T, Aoyama M, Obara T, Yasuda N, Akama H, Kawano T, Imai T, Ieiri I, Kumagai Y. FIRST-IN-HUMAN (FIH) STUDY OF E6011, A NOVEL HUMANIZED ANTI-FRACTALKINE (CX3CL1) MONOCLONAL ANTIBODY. ASCPT 2016 Annual Meeting. San Diego, CA, USA. Mar 10 (2016).
2015
Vu H.L, Chino Y, Hasegawa M, Kuboi Y, Obara T, Yasuda N, Muramoto K, Imai T. Anti-CX3CL1 monoclonal antibody: a promising therapy for systemic sclerosis. 40th Annual Meeting of the Japanese Society for Investigative Dermatology. Okayama, Japan. Dec 11 (2015)
Tanaka Y, Takeuchi T, Umehara H, Nanki T, Akama H, Yasuda N, Tago F, Kawakubo M, Hojo S, Kawano T, Imai T. Safety and Efficacy of E6011, an Anti-Fractalkine Monoclonal Antibody, in a First-in-Patient Phase 1/2 Study in Rheumatoid Arthritis. American College of Rheumatology Annual Meeting. San Francisco, USA. Nov 10 (2015)
Ikeda W, Hamaguchi A, Arita Y, Kuboi Y, Muramoto K, Imai T. Advanced in vivo live imaging of vascular network of colon submucosa in IBD models using two-photon laser microscopy. Digestive Disease Week (DDW) 2015. Washington D.C., USA. May 16 (2015).
Motoi S, Okuro M, Ikeda W, Hamaguchi A, Muramoto K, Sato T, Yasuda N, Kajiwara A, Kawano T, Imai T. Inflammation via the Fractalkine (CX3CL1)/CX3CR1 Pathway Is Distinct from the TNF Pathway in Murine Colitis Model. Digestive Disease Week (DDW) 2015. Washington D.C., USA. May 18 (2015).
