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Relapse and metastasis are the challenging clinical problems and the causes of most deaths from cancer. Surgical resection, chemotherapy, immunotherapy, and radiation therapy have provided survival benefit for cancer patients, and there has been increasing hope that novel molecularly-targeted therapies would be efficacious in the treatment of specific tumors. However, despite decades of intensive efforts to find effective therapy, the median survival of patient with relapsed tumors or metastatic cancers had not changed appreciably. Thus, treatment and prevention of relapse and metastasis are major unmet needs that can be improved by a better understanding of the molecular basis of these events.
Relapse and metastasis are complex clinical and biological problems. We have been creating new models that well-recapitulate human cancers' features, including pathological appearances, molecular profiles and clinical processes of relapse and metastasis. By collaborative research with academia and clinicians, we are attempting to discover the early detection method and find attractive therapeutic targets, which would create great hope for patients suffering from malignant cancers.
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