論文リスト

原著

2019年
Kishida N, Maki T, Takagi Y, Yasuda K, Kinoshita H, Ayaki T, Noro T, Kinoshita Y, Ono Y, Kataoka H, Yoshida K, Lo EH, Arai K, Miyamoto S, Takahashi R. Role of Perivascular Oligodendrocyte Precursor Cells in Angiogenesis After Brain Ischemia. J Am Heart Assoc. May 7;8(9)(2019)

Motoi S,Toyoda H,Obara T,Ohta E,Arita Y,Negishi K,Moriya K,Kuboi Y,Soejima M,Imai T,Ido A,Tsubouchi H,Kawano T. Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time. Int J Mol Sci. Apr 12;20(8)(2019)

Hoshino-Negishi K, Ohkuro M, Nakatani T, Kuboi Y, Nishimura M, Ida Y, Kakuta J, Hamaguchi A, Kumai M, Kamisako T, Sugiyama F, Ikeda W, Ishii N, Yasuda N, Imai T. Role of Anti-Fractalkine Antibody in Suppression of Joint Destruction by Inhibiting Migration of Osteoclast Precursors to the Synovium in Experimental Arthritis. Arthritis & Rheumatology. Feb;71(2):222-231.(2019)

Morita N, Umemoto E, Fujita S, Hayashi A, Kikuta J, Kimura I, Haneda T, Imai T, Inoue A, Mimuro H, Maeda Y, Kayama H, Okumura R, Aoki J, Okada N, Kida T, Ishii M, Nabeshima R, Takeda K. GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites. Nature. Feb;566(7742):110-114.(2019)

2018年
Ikeda W, Nakatani T, Uemura A. Cataract-preventing contact lens for in vivo imaging of mouse retina. BioTechniques. Aug 9;65(2)(2018)

Sasaki A, Nagatake T, Egami R, Takigawa I, Ikeda W, Nakatani T, Kunisawa J, Fujita Y. Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues. Cell Rep. Apr 24;23(4):974-982.(2018)

Tanaka Y, Takeuchi T, Umehara H, Nanki T, Yasuda N, Tago F, Kawakubo M, Kitahara Y, Hojo S, Kawano T, Imai T. Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis. Mod Rheumatol. Jan;28(1):58-65.(2018)

2017年
Vibulyaseck S, Fujita H, Luo Y, Tran AK, Oh-Nishi A, Ono Y, Hirano S, Sugihara I. Spatial rearrangement of Purkinje cell subsets forms the transverse and longitudinal compartmentalization in the mouse embryonic cerebellum. J Comp Neurol. Oct 1;525(14):2971-2990.(2017)

Sasai K, Takao-Rikitsu E, Sukezane T, Yanagita E, Nakagawa H, Itoh-Yagi M, Izumi Y, Itoh T, Akagi T. Engineering cancer stem-like cells from normal human lung epithelial cells. PLoS One. Apr 5;12(4)(2017)

Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro-Oonuma T, Hwang Y, Ahn S, Park I, Ikeda W, Kusuhara S, Fukushima Y, Nara H, Sakai H, Fujiwara T, Matsuhita J, Ema M, Hirashima M, Minami T, Shibuya M, Takakura N, Kim P, Miyata T, Ogura Y, Uemura A. Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown. JCI Insight. Feb 9;2(3) (2017)

Ito S, Izumi Y, Niidome T, Ono Y. Methylcobalamin prevents mutant SOD1-induced motor neuron death in vitro. Neuroreport. Jan Volume 28(2)101–107(2017)

2016年
Kojima C, Fusaoka-Nishioka E, Imai T, Nakahira A, Onodera H. Dendrigraft polylysine coated-poly (glycolic acid) fibrous scaffolds for hippocampal neurons. J Biomed Mater Res A. Nov;104(11):2744-50.(2016)

Samata B, Doi D, Nishimura K, Kikuchi T, Watanabe A, Sakamoto Y, Kakuta J, Ono Y, Takahashi J. Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1. Nat Commun. Oct 14;7(13097) (2016)

Hayashizaki K, Kimura Y M, Tokoyoda K, Hosokawa H, Shinoda K, Hirahara K, Ichikawa T, Onodera A, Hanazawa A, Iwamura C, Kakuta J, Muramoto K, Motohashi S, Tumes J D, Iinuma T, Yamamoto H, Ikehara Y, Okamoto Y, Nakayama T. Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation. Sci Immunol. Sep 16;1(3): eaaf9154.(2016)

Kobayashi S, Hida Y, Ishizaki H, Inoue E, Tanaka-Okamoto M, Yamasaki M, Miyazaki T, Fukaya M, Kitajima I, Takai Y, Watanabe M, Ohtsuka T, Manabe T. The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus. Eur J Neurosci. Sep;44(5):2272-84.(2016)

2014年
Ishii N, Wakita H, Shirato M. Effect of the phosphodiesterase 4 inhibitor E6005 on nerve growth factor elevation in irritated skin of NC/Nga mice. J Dermatol Sci. Dec;76(3):263-4.(2014)

Hagiwara A, Yasumura M, Hida Y, Inoue E, Ohtsuka T. The planar cell polarity protein Vangl2 bidirectionally regulates dendritic branching in cultured hippocampal neurons. Mol Brain. 7(1):79.(2014)

Tanaka K, Shiota J, Mikami M, Inoue Y, Sumida T, Matsumoto I, Muramoto K. The combined effects of iguratimod with anti-TNFα antibody on experimental arthritis models in mice. Inflamm Regen. May;34(3):157-164.(2014)

Nakatani T, Minaki Y, Kumai M, Nitta C, Ono Y. The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells. Dev Biol. Apr 1;388(1):68-80.(2014)

Doi D, Samata B, Katsukawa M, Kikuchi T, Morizane A, Ono Y, Sekiguchi K, Nakagawa M, Parmar M, Takahashi J. Isolation of Human Induced Pluripotent Stem Cell-derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation. Stem Cell Reports. Mar 6;2(1):337–350.(2014)

Seto Y , Nakatani T , Masuyama N , Taya S , Kumai M , Minaki Y , Hamaguchi A , Inoue YU , Inoue T , Miyashita S , Fujiyama T , Yamada M , Chapman H , Campbell KJ , Magnuson MA , Wright CV , Kawaguchi Y, Ikenaka K , Takebayashi H , Ishiwata S , Ono Y , Hoshino M . Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum. Nat Commun. Feb 18;5(3337):(2014)

2013年
Yamada T, Kuramitsu K, Rikitsu E, Kurita S, Ikeda W, Takai Y. Nectin and JAM are critical cell adhesion molecules for the apico-basal alignment of adherens and tight junctions in epithelial cells. Genes Cells. Nov;18(11):985-98.(2013)

Kurita S, Yamada T, Rikitsu E, Ikeda W, Takai Y. Binding between the Junctional Proteins Afadin and PLEKHA7 and Implication in the Formation of Adherens Junction in Epithelial Cells. J Biol Chem. Oct 11;288(41):29356-6.(2013)

Yamada A, Inoue E, Deguchi-Tawarada M, Matsui C, Togawa A, Nakatani T, Ono Y, Takai Y. Necl-2/CADM1 interacts with ErbB4 and regulates its activity in GABAergic neurons. Mol Cell Neurosci. Sep;56:234-243.(2013)

Kitagawa Y, Kikuchi S, Arita Y, Nishimura M, Mizuno K, Ogasawara H, Kawano T, Ochiai T, Otsuji E, Imai T. Inhibition of CCL20 increases mortality in models of mouse sepsis with intestinal apoptosis. Surgery. Jul;154(1):78-88.(2013)

Hoshino A, Ueha S, Hanada S, Imai T, Ito M, Yamamoto K, Matsushima K, Yamaguchi A, Iimura T. Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts. J Cell Sci. Feb 15;126(4):1032-1045.(2013)

2012年
Sakane A, Abdallah AAM, Nakano K, Honda K, Ikeda W, Nishikawa Y, Matsumoto M, Matsushita N, Kitamura T, Sasaki T. Rab13 small G protein and junctional Rab13-binding protein (JRAB) orchestrate actin cytoskeletal organization during epithelial junctional development. J Biol Chem. Dec 14;287(51):42455-42468.(2012)

Matsui C, Inoue E, Kakita A, Arita K, Deguchi-Tawarada M, Togawa A, Yamada A, Takai Y, Takahashi H. Involvement of the (gamma)-secretase-mediated EphA4 signaling pathway in synaptic pathogenesis of Alzheimer's disease. Brain Pathol. Nov;22(6):776-787.(2012)

Dieck ST, Specht D, Strenzke N, Hida Y, Krishnamoorthy V, Schmidt K-F, Inoue E, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Hagiwara A, Brandstatter JH, Lowel S, Gollisch T, Ohtsuka T, Moser T. Deletion of the presynaptic scaffold cast reduces active zone size in rod photoreceptors and impairs visual processing. J Neurosci. Aug 29;32(35):12192-12203.(2012)

Kitagawa M, Takebe A, Ono Y, Imai T, Nakao K, Nishikawa S, Era T. Phf14, a novel regulator of mesenchyme growth via platelet-derived growth factor (PDGF) receptor-(alpha). J Biol Chem. Aug 10;287(33):27983-27996.(2012)

Suzuki F, Kubota T, Miyazaki Y, Ishikawa K, Ebisawa M, Hirohata S, Ogura T, Mizusawa H, Imai T, Miyasaka N, Nanki T. Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity. Arthritis Res Ther. Mar 6;14(2):R48.(2012)

Mori T, Shimizu N, Jinno-Oue A, Tanaka A, Shinagawa M, Tokizawa S, Akagi T, Hoshino H. Tax1-expressing feline 8C cells are useful to monitor the life cycle of human T-cell leukemia virus type I. J Gen Virol. Mar;93(Pt 3):588-93.(2012)

2011年
Fusaoka-Nishioka E, Shimono C, Taniguchi Y, Togawa A, Yamada A, Inoue E, Onodera H, Sekiguchi K, Imai T. Differential effects of laminin isoforms on axon and dendrite development in hippocampal neurons. Neurosci Res. Dec;71(4):421-426.(2011)

Kaneko K, Miyabe Y, Takayasu A, Fukuda S, Miyabe C, Ebisawa M, Yokoyama W, Watanabe K, Imai T, Muramoto K, Terashima Y, Sugihara T, Matsushima K, Miyasaka N, Nanki T. Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis. Arthritis Res Ther. Sep 29;13(5):Article Number: R158.(2011)

Kiyozumi D, Osada A, Sugimoto N, Weber CN, Ono Y, Imai T, Okada A, Sekiguchi K. Identification of genes expressed during hair follicle induction. J Dermatol. Jul;38(7):674-679.(2011)

Hida Y, Fukaya M, Hagiwara A, Deguchi-Tawarada M, Yoshioka T, Kitajima I, Inoue E, Watanabe M, Ohtsuka T. Prickle2 is localized in the postsynaptic density and interacts with PSD-95 and NMDA receptors in the brain. J Biochem. Jun;149(6):693-700.(2011)

Sasai K, Sukezane T, Yanagita E, Nakagawa H, Hotta A, Itoh T, Akagi T. Oncogene-mediated human lung epithelial cell transformation produces adenocarcinoma phenotypes in vivo. Cancer Res. Apr 1;71(7):2541-2549.(2011)

2010年
Tagi T, Matsui T, Kikuchi S, Hoshi S, Ochiai T, Kokuba Y, Kinoshita-Ida Y, Kisumi-Hayashi F, Morimoto K, Imai T, Imoto I, Inazawa J, Otsuji E. Dermokine as a novel biomarker for early-stage colorectal cancer. J Gastroenterol. Dec 2010;45(12):1201-1211.(2010)

Muguruma K, Nishiyama A, Ono Y, Miyawaki H, Mizuhara E, Hori S, Kakizuka A, Obata K, Yanagawa Y, Hirano T, Sasai Y. Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells. Nat Neurosci. Oct 2010;13(10):1171-1180.(2010)

Tanji M, Ishizaki T, Ebrahimi S, Tsuboguchi Y, Sukezane T, Akagi T, Frame MC, Hashimoto N, Miyamoto S, Narumiya S. mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion. Mol Cell Biol. Oct 30;19:4604-15.(2010)

Hoshino A, Iimura T, Ueha S, Hanada S, Maruoka Y, Mayahara M, Suzuki K, Imai T, Ito M, Manome Y, Yasuhara M, Kirino T, Yamaguchi A, Matsushima K, Yamamotoa K. Deficiency of chemokine receptor CCR1 causes osteopenia due to impaired functions of osteoclasts and osteoblasts. J Biol Chem. Sep 10;285(37):28826-28837.(2010)

Miyata T, Ono Y, Okamoto M, Masaoka M, Sakakibara A, Kawaguchi A, Hashimoto M, Ogawa M. Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum. Neural Dev. Sep;5:23.(2010)

Kaieda S, Matsui C, Mimori-Kiyosue Y, Ikegami T. Structural basis of the recognition of the samp motif of adenomatous polyposis coli by the src-homology 3 domain. Biochemistry. Jun 29;49(25):5143-5153.(2010)

Ono Y, Nakatani T, Minaki Y, Kumai M. The basic helix-loop-helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells. Development. Jun 1;137(11):1897-1906.(2010)

Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y. Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5(alpha)/(beta). J Cell Biol. May 31;189(5):901-917.(2010)

Muto S, Hata M, Taniguchi J, Tsuruoka S, Moriwaki K, Saitou M, Furuse K, Sasaki H, Fujimura A, Imai M, Kusano E, Tsukita S, Furuse M. Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. Proc Natl Acad Sci U S A. Apr 27;107(17):8011-8016.(2010)

Masuda K, Katagiri C, Nomura M, Sato M, Kakumoto K, Akagi T, Kikuchi K, Tanuma N, Shima H. MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm. Biochem Biophys Res Commun. Mar 5;393(2):201-6.(2010)

Nakatani T, Kumai M, Mizuhara E, Minaki Y, Ono Y. Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon. Dev Biol. Mar 1;339(1):101-113.(2010)

Mizuhara E, Minaki Y, Nakatani T, Kumai M, Inoue T, Muguruma K, Sasai Y, Ono Y. Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin. Dev Biol. Feb 15;338(2):202-214.(2010)

2009年
Koizumi K, Saitoh Y, Minami T, Takeno N, Tsuneyama K, Miyahara T, Nakayama T, Sakurai H, Takano Y, Nishimura M, Imai T, Yoshie O, Saiki I. Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption. J Immunol. Dec 15;183(12):7825-7831.(2009)

Jonsson M.E, Ono Y, Bjorklund A, Thompson L.H. Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis. Exp Neurol. Sep;219(1):341-354.(2009)

Mori D, Yamada M, Mimori-Kiyosue Y, Shirai Y, Suzuki A, Ohno S, Saya H, Wynshaw-Boris A, Hirotsune S. An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics. Nat Cell Biol. Aug;11(9):1057-1068.(2009)

Inoue E, Deguchi-Tawarada M, Togawa A, Matsui C, Arita K, Katahira-Tayama S, Sato T, Yamauchi E, Oda Y, Takai Y. Synaptic activity prompts (gamma)-secretase-mediated cleavage of EphA4 and dendritic spine formation. J Cell Biol. May 4;185(3):551-564.(2009)

Tanaka-Okamoto M, Hori K, Ishizaki H, Hosoi A, Itoh Y, Wei M, Wanibuchi H, Mizoguchi A, Nakamura H, Miyoshi J. Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7. Cancer Sci. Apr;100(4):608-616.(2009)

Abe A, Fukui H, Fujii S, Kono T, Mukawa K, Yoshitake N, Sekikawa A, Ichikawa K, Tomita S, Yamagishi H, Imai Y, Shinoda M, Ishizaki H, Tanaka-Okamoto M, Kubota K, Miyoshi J, Takai Y, Fujimori T. Role of Necl-5 in the pathophysiology of colorectal lesions induced by dimethylhydrazine and/or dextran sodium sulphate. J Pathol. Jan;217(1):42-53.(2009)

2008年
Matsui C, Kaieda S, Ikegami T, Mimori-Kiyosue Y. Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF. J Biol Chem. Nov 21;283(47):33006-33020.(2008)

Yamada M, Toba S, Yoshida Y, Haratani K, Mori D, Yano Y, Mimori-Kiyosue Y, Nakamura T, Itoh K, Fushiki S, Setou M, Wynshaw-Boris A, Torisawa T, Toyoshima YY, Hirotsune S. LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein. EMBO J. Oct 8;27(19):2471-2483.(2008)

Minaki Y, Nakatani T, Mizuhara E, Inoue T, Ono Y. Identification of a novel transcriptional corepressor, Corl2, as a cerebellar Purkinje cell-selective marker. Gene Expr Patterns. Jul;8(6):418-423.(2008)

Fujiwara T, Kawakatsu T, Tayama S, Kobayashi Y, Sugiura N, Kimata K, Takai Y. Hyaluronan-CD44 pathway regulates orientation of mitotic spindle in normal epithelial cells. Genes Cells. Jul;13(7):759-770.(2008)

Holmes FE, Arnott N, Vanderplank P, Kerr NCH, Longbrake EE, Popovich PG, Imai T, Combadiere C, Murphy PM, Wynick D. Intra-neural administration of fractalkine attenuates neuropathic pain-related behaviour. J Neurochem. Jul;106(2):640-649.(2008)

Katsuno T, Umeda K, Matsui T, Hata M, Tamura A, Itoh M, Takeuchi K, Fujimori T, Nabeshima YI, Noda T, Tsukita S, Tsukita S. Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell. Jun;19(6):2465-2475.(2008)

Amano H, Ikeda W, Kawano S, Kajita M, Tamaru Y, Inoue N, Minami Y, Yamada A, Takai Y. Interaction and localization of Necl-5 and PDGF receptor (beta) at the leading edges of moving NIH3T3 cells: Implications for directional cell movement. Genes Cells. Mar;13(3):269-284.(2008)

Morimoto K, Satoh-Yamaguchi K, Hamaguchi A, Inoue Y, Takeuchi M, Okada M, Ikeda W, Takai Y, Imai T. Interaction of cancer cells with platelets mediated by Necl-5/poliovirus receptor enhances cancer cell metastasis to the lungs. Oncogene. Jan 10;27(3):264-273.(2008)

Hayashi H, Morizane A, Koyanagi M, Ono Y, Sasai Y, Hashimoto N, Takahashi J. Meningeal cells induce dopaminergic neurons from embryonic stem cells. Eur J Neurosci. Jan;27(2):261-268.(2008)

2007年
Nishimura K, Kitamura Y, Inoue T, Umesono Y, Sano S, Yoshimoto K, Inden M, Takata K, Taniguchi T, Shimohama S, Agata K. Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates. Dev Neurobiol. July;67(8):1059-1078.(2007)

Kobayashi T, Okamoto S, Iwakami Y, Nakazawa A, Hisamatsu T, Chinen H, Kamada N, Imai T, Goto H, Hibi T. Exclusive increase of CX3CR1(+)CD28(-)CD4(+) T cells in inflammatory bowel disease and their recruitment as intraepithelial lymphocytes. Inflamm Bowel Dis. July;13(7):837-846.(2007)

Mizutani N, Sakurai T, Shibata T, Uchida K, Fujita J, Kawashima R, Kawamura YI, Toyama-Sorimachi N, Imai T, Dohi T. Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. J Immunol. Dec 1;179(11):7478-7487.(2007)

Ono Y, Nakatani T, Sakamoto Y, Mizuhara E, Minaki Y, Kumai M, Hamaguchi A, Nishimura M, Inoue Y, Hayashi H, Takahashi J, Imai T. Differences in neurogenic potential in floor plate cells along an anteroposterior location: Midbrain dopaminergic neurons originate from mesencephalic floor plate cells. Development. Sep;134(17):3213-3225.(2007)

Nishimura K, Kitamura Y, Inoue T, Umesono Y, Yoshimoto K, Takeuchi K, Taniguchi T, Agata K. Identification and distribution of tryptophan hydroxylase (TPH)-positive neurons in the planarian Dugesia japonica. Neurosci Res. Sep;59(1):101-106.(2007)

Kotake Y, Sagane K, Owa T, Mimori-Kiyosue Y, Shimizu H, Uesugi M, Ishihama Y, Iwata M, Mizui Y. Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol. Sep;3(9):570-575.(2007)

Nakatani T, Minaki Y, Kumai M, Ono Y. Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon. Development. Aug;134(15):2783-2793.(2007)

Takahashi K, Yoshida N, Murakami N, Kawata K, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Zinn AR, Shime H, Inoue N. Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol Biol Cell. May;18(5):1701-1709.(2007)

Inoue T, Hayashi T, Takechi K, Agata K. Clathrin-mediated endocytic signals are required for the regeneration of, as well as homeostasis in, the planarian CNS. Development. May;134(9):1679-1689.(2007)

Sugihara-Mizuno Y, Adachi M, Kobayashi Y, Hamazaki Y, Nishimura M, Imai T, Furuse M, Tsukita S. Molecular characterization of angiomotin/JEAP family proteins: Interaction with MUPP1/Patj and their endogenous properties. Genes Cells. Apr;12(4):473-486.(2007)

Higa S, Tokoro T, Inoue E, Kitajima I, Ohtsuka T. The active zone protein CAST directly associates with Ligand-of-Numb protein X. Biochem Biophys Res Commun. Mar 16;354(3):686-692.(2007)

Tokoro T, Higa S, Deguchi M, Inoue E, Kitajima I, Ohtsuka T. Localization of the active zone proteins CAST, ELKS, and Piccolo at neuromuscular junctions. Neuroreport. Mar 5;18(4):313-6.(2007)

Fukumoto K, Kikuchi S, Itoh N, Tamura A, Hata M, Yamagishi H, Tsukita S, Tsukita S. Effects of genetic backgrounds on hyperbilirubinemia in radixin-deficient mice due to different expression levels of Mrp3. Bba-Mol Basis Dis. Mar;1772(3):298-306.(2007)

Mimori-Kiyosue Y, Matsui C, Sasaki H, Tsukita S. Adenomatous polyposis coli (APC) protein regulates epithelial cell migration and morphogenesis via PDZ domain-based interactions with plasma membranes. Genes Cells. Feb;12(2):219-233.(2007)

Nishimoto G, Sasaki G, Yaoita E, Nameta M, Li H, Furuse K, Fujinaka H, Yoshida Y, Mitsudome A, Yamamoto T. Molecular characterization of water-selective AQP (EbAQP4) in hagfish: Insight into ancestral origin of AQP4. Am J Physiol-Reg I. Jan;292(1):R644-R651.(2007)

Ueha S, Murai M, Yoneyama H, Kitabatake M, Imai T, Shimaoka T, Yonehara S, Ishikawa S, Matsushima K. Intervention of MAdCAM-1 or fractalkine alleviates graft-versus-host reaction associated intestinal injury while preserving graft-versus-tumor effects. J Leukoc Biol. Jan;81(1):176-185.(2007)

2006年
Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, Ohtsuka T, Higa S, Kitajima I, Demmers J, Galjart N, Houtsmuller AB, Grosveld F, Akhmanova A. CLASPs Attach Microtubule Plus Ends to the Cell Cortex through a Complex with LL5(beta). Dev Cell. July;11(1):21-32.(2006)

Ishizaki H, Togawa A, Tanaka-Okamoto M, Hori K, Nishimura M, Hamaguchi A, Imai T, Takai Y, Miyoshi J. Defective chemokine-directed lymphocyte migration and development in the absence of Rho guanosine diphosphate-dissociation inhibitors (alpha) and (beta). J Immunol. Dec 15;177(12):8512-8521.(2006)

Adachi M, Inoko A, Hata M, Furuse K, Umeda K, Itoh M, Tsukita S. Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein. Mol Cell Biol. Dec;26(23):9003-9015.(2006)

Matsui T, Kinoshita-Ida Y, Hayashi-Kisumi F, Hata M, Matsubara K, Chiba M, Katahira-Tayama S, Morita K, Miyachi Y, Tsukita S. Mouse homologue of skin-specific retroviral-like aspartic protease involved in wrinkle formation. J Biol Chem. Sep 15;281(37):27512-27525.(2006)

Inagaki M, Irie K, Ishizaki H, Tanaka-okamoto M, Miyoshi J, Takai Y. Role of cell adhesion molecule nectin-3 in spermatid development. Genes Cells. Sep;11(9):1125-1132.(2006)

Umeda K, Ikenouchi J, Katahira-Tayama S, Furuse K, Sasaki H, Matsui T, Tsukita S, Furuse M, Tsukita S. ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation. Cell. Aug 25;126(4):741-754.(2006)

Yamada A, Fujita N, Sato T, Okamoto R, Ooshio T, Hirota T, Morimoto K, Irie K, Takai Y. Requirement of nectin, but not cadherin, for formation of claudin-based tight junctions in annexin II-knockdown MDCK cells. Oncogene. Aug 24;25(37):5085-5102.(2006)

Mimori-Kiyosue Y, Grigoriev I, Sasaki H, Matsui C, Akhmanova A, Tsukita S, Vorobjev I. Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. Genes Cells. Aug;11(8):845-857.(2006)

Inoue E, Deguchi-Tawarada M, Takao-Rikitsu E, Inoue M, Kitajima I, Ohtsuka T, Takai Y. ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca(2+)-dependent exocytosis from PC12 cells. Genes Cells. Jun;11(6):659-672.(2006)

Fusaoka E, Inoue T, Mineta K, Agata K, Takeuchi K. Structure and function of primitive immunoglobulin superfamily neural cell adhesion molecules: A lesson from studies on planarian. Genes Cells. May;11(5):541-555.(2006)

Inoue E, Mochida S, Takagi H, Higa S, Deguchi-Tawarada M, Takao-Rikitsu E, Inoue M, Yao I, Takeuchi K, Kitajima I, Setou M, Ohtsuka T, Takai Y. SAD: A Presynaptic Kinase Associated with Synaptic Vesicles and the Active Zone Cytomatrix that Regulates Neurotransmitter Release. Neuron. Apr 20;50(2):261-275.(2006)

Ohmori K, Fukui F, Kiso M, Imai T, Yoshie O, Hasegawa H, Matsushima K, Kannagi R. Identification of cutaneous lymphocyte-associated antigen as sialyl 6-sulfo Lewis X, a selectin ligand expressed on a subset of skin-homing helper memory T cells. Blood. Apr 15;107(8):3197-3204.(2006)

Deguchi-Tawarada M, Inoue E, Takao-Rikitsu E, Inoue M, Kitajima I, Ohtsuka T, Takai Y. Active zone protein CAST is a component of conventional and ribbon synapses in mouse retina. J Comp Neurol. Apr 1;495(4):480-496.(2006)

Honda T, Sakisaka T, Yamada T, Kumazawa N, Hoshino T, Kajita M, Kayahara T, Ishizaki H, Tanaka-Okamoto M, Mizoguchi A, Manabe T, Miyoshi J, Takai Y. Involvement of nectins in the formation of puncta adherentia junctions and the mossy fiber trajectory in the mouse hippocampus. Mol Cell Neurosci. Feb;31(2):315-325.(2006)

2005年
Ikenouchi J, Furuse M, Furuse K, Sasaki H, Tsukita S, Tsukita S. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol. Dec 19;171(6):939-945.(2005)

Suzuki F, Nanki T, Imai T, Kikuchi H, Hirohata S, Kohsaka H, Miyasaka N. Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice. J Immunol. Nov 15;175(10):6987-6996.(2005)

Komiya S, Shimizu M, Ikenouchi J, Yonemura S, Matsui T, Fukunaga Y, Liu H, Endo F, Tsukita S, Nagafuchi A. Apical membrane and junctional complex formation during simple epithelial cell differentiation of F9 cells. Genes Cells. Nov;10(11):1065-1080.(2005)

Hagiwara A, Fukazawa Y, Deguchi-Tawarada M, Ohtsuka T, Shigemoto R. Differential distribution of release-related proteins in the hippocampal CA3 area as revealed by freeze-fracture replica labeling. J Comp Neurol. Aug 22;489(2):195-216.(2005)

Mizuhara E, Nakatani T, Minaki Y, Sakamoto Y, Ono Y, Takai Y. MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface. J Biol Chem. Jul 15;280(28):26499-26507.(2005)

Kawagishi R, Tahara M, Morishige K, Sakata M, Tasaka K, Ikeda W, Morimoto K, Takai Y, Murata Y. Expression of nectin-2 in mouse granulosa cells. Eur J Obstet Gyn R B. Jul 1;121(1):71-76.(2005)

Minaki Y, Mizuhara E, Morimoto K, Nakatani T, Sakamoto Y, Inoue Y, Satoh K, Imai T, Takai Y, Ono Y. Migrating postmitotic neural precursor cells in the ventricular zone extend apical processes and form adherens junctions near the ventricle in the developing spinal cord. Neurosci Res. Jul;52(3):250-262.(2005)

Ohara-Imaizumi M, Ohtsuka T, Matsushima S, Akimoto Y, Nishiwaki C, Nakamichi Y, Kikuta T, Nagai S, Kawakami H, Watanabe T, Nagamatsu S. ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic (beta) cells and functions in insulin exocytosis: Interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy. Mol Biol Cell. Jul;16(7):3289-3300.(2005)

Kanaya H, Takeya R, Takeuchi K, Watanabe N, Jing N, Sumimoto H. Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament. Genes Cells. Jul;10(7):665-678.(2005)

Yuba-Kubo A, Kubo A, Hata M, Tsukita S. Gene knockout analysis of two (gamma)-tubulin isoforms in mice. Dev Biol. Jun 15;282(2):361-373.(2005)

Kiyozumi D, Osada A, Sugimoto N, Weber CN, Ono Y, Imai T, Okada A, Sekiguchi K. Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle. Exp Cell Res. May 15;306(1):9-23.(2005)

Miyamoto T, Morita K, Takemoto D, Takeuchi K, Kitano Y, Miyakawa T, Nakayama K, Okamura Y, Sasaki H, Miyachi Y, Furuse M, Tsukita S. Tight junctions in Schwann cells of peripheral myelinated axons: A lesson from claudin-19-deficient mice. J Cell Biol. May 9;169(3):527-538.(2005)

Miyazaki T, Ono M, Qu W-M, Zhang M-C, Mori S, Nakatsuru S, Nakamura Y, Sawasaki T, Endo Y, Nose M. Implication of allelic polymorphism of osteopontin in the development of lupus nephritis in MRL/lpr mice. Eur J Immunol. May;35(5):1510-1520.(2005)

Sawai H, Park YW, Roberson J, Imai T, Goronzy JJ, Weyand CM. T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis. Arthritis Rheum. May;52(5):1392-1401.(2005)

Inoue A, Hasegawa H, Kohno M, Ito MR, Terada M, Imai T, Yoshie O, Nose M, Fujita S. Antagonist of fractalkine (CX3CL1) delays the initiation and ameliorates the progression of lupus nephritis in MRL/lpr mice. Arthritis Rheum. May;52(5):1522-1533.(2005)

Okamoto K, Takeuchi K, Agata K. Neural projections in planarian brain revealed by fluorescent dye tracing. Zoolog Sci. May;22(5):535-546.(2005)

Tamura A, Kikuchi S, Hata M, Katsuno T, Matsui T, Hayashi H, Suzuki Y, Noda T, Tsukita S, Tsukita S. Achlorhydria by ezrin knockdown: Defects in the formation/expansion of apical canaliculi in gastric parietal cells. J Cell Biol. Apr 11;169(1):21-28.(2005)

Sasakura H, Inada H, Kuhara A, Fusaoka E, Takemoto D, Takeuchi K, Mori I. Maintenance of neuronal positions in organized ganglia by SAX-7, a Caenorhabditis elegans homologue of L1. EMBO J. Apr 6;24(7):1477-1488.(2005)

Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y. Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. Development. Apr;132(7):1525-1537.(2005)

Li H-P, Honma S, Miki T, Takeuchi Y, Takeuchi K, Kawano H. Multiple defects in the formation of rat cortical axonal pathways following prenatal X-ray irradiation. Eur J Neurosci. Apr;21(7):1847-1858.(2005)

Nakamura H, Mukai M, Komatsu K, Tanaka-Okamoto M, Itoh Y, Ishizaki H, Tatsuta M, Inoue M, Miyoshi J. Transforming growth factor-(beta)1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells. Cancer Lett. Mar 18;220(1):95-99.(2005)

Kakunaga S, Ikeda W, Itoh S, Deguchi-Tawarada M, Ohtsuka T, Mizoguchi A, Takai Y. Nectin-like molecule-1/TSLL1/SynCAM3: A neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes. J Cell Sci. Mar 15;118(6):1267-1277.(2005)

Mizuhara E, Nakatani T, Minaki Y, Sakamoto Y, Ono Y. Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1. J Biol Chem. Feb 4;280(5):3645-3655.(2005)

Osada A, Kiyozumi D, Tsutsui K, Ono Y, Weber CN, Sugimoto N, Imai T, Okada A, Sekiguchi K. Expression of MAEG, a novel basement membrane protein, in mouse hair follicle morphogenesis. Exp Cell Res. Feb 1;303(1):148-159.(2005)

Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, Sasaki H, Matsui C, Severin F, Galjart N, Grosveld F, Vorobjev I, Tsukita S, Akhmanova A. CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. J Cell Biol. Jan 3;168(1):141-153.(2005)

2004年
Nanki T, Urasaki Y, Imai T, Nishimura M , Muramoto K, Kubota T, Miyasaka N. Inhibition of fractalkine ameliorates murine collagen-induced arthritis. J Immunol. Dec 1;173(11):7010-7016.(2004)

Ohnishi H, Nakahara T, Furuse K, Sasaki H, Tsukita S, Furuse M. JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin. J Biol Chem. Oct 29;279(44):46014-46022.(2004)

Umeda K, Matsui T, Nakayama M, Furuse E, Sasaki H, Furuse M, Tsukita S. Establishment and characterization of cultured epithelial cells lacking expression of ZO-1. J Biol Chem. Oct 22;279(43):44785-44794.(2004)

Kitajiri SI, Miyamoto T, Mineharu A, Sonoda N, Furuse K, Hata M, Sasaki H, Mori Y, Kubota T, Ito J, Furuse M, Tsukita S. Compartmentalization established by claudin-11-based tight junctions in stria vascularis is required for hearing through generation of endocochlear potential. J Cell Sci. Oct 1;117(21):5087-5096.(2004)

Okabe N, Shimizu K, Ozaki-Kuroda K, Nakanishi H, Morimoto K, Takeuchi M, Katsumaru H, Murakami F, Takai Y. Contacts between the commissural axons and the floor plate cells are mediated by nectins. Dev Biol. Sep 15;273(2):244-256.(2004)

Sugimoto K, Ohata M, Miyoshi J, Ishizaki H, Tsuboi N, Masuda A, Yoshikai Y, Takamoto M, Sugane K, Matsuo S, Shimada Y, Matsuguchi T. A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. J Clin Investig. Sep;114(6):857-866.(2004)

Kakunaga S, Ikeda W, Shingai T, Fujito T, Yamada A, Minami Y, Imai T, Takai Y. Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. Aug 27;279(35):36419-36425.(2004)

Kitajiri SI, Fukumoto K, Hata M, Sasaki H, Katsuno T, Nakagawa T, Ito J, Tsukita S, Tsukita S. Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia. J Cell Biol. Aug 16;166(4):559-570.(2004)

Matsui T, Hayashi-Kisumi F, Kinoshita Y , Katahira S, Morita K, Miyachi Y, Ono Y, Imai T, Tanigawa Y, Komiya T, Tsukita S. Identification of novel keratinocyte-secreted peptides dermokine-(alpha)/- (beta) and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1. Genomics. Aug;84(2):384-397.(2004)

Ooshio T, Irie K, Morimoto K, Fukuhara A, Imai T, Takai Y. Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and (alpha)-actinin in epithelial cells. J Biol Chem. Jul 23;279(30):31365-31373.(2004)

Izumi G, Sakisaka T, Baba T, Tanaka S, Morimoto K, Takai Y. Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments. J Cell Biol. Jul 19;166(2):237-248.(2004)

Ikeda W, Kakunaga S, Takekuni K, Shingai T, Satoh K, Morimoto K, Takeuchi M, Imai T, Takai Y. Nectin-like Molecule-5/Tage4 Enhances Cell Migration in an Integrin-dependent, Nectin-3-independent Manner. J Biol Chem. Apr 23;279(17):18015-18025.(2004)

Nakatani T, Mizuhara E, Minaki Y, Sakamoto Y, Ono Y. Helt, a Novel Basic-Helix-Loop-Helix Transcriptional Repressor Expressed in the Developing Central Nervous System. J Biol Chem. Apr 16;279(16):16356-16367.(2004)

Yoshikawa M, Nakajima T, Matsumoto K, Okada N, Tsukidate T, Iida M, Otori N, Haruna SI, Moriyama H, Imai T, Saito H. TNF-(alpha) and IL-4 regulate expression of fractalkine (CX(3)CL1) as a membrane-anchored proadhesive protein and soluble chemotactic peptide on human fibroblasts. FEBS Lett. Mar 12;561(1-3):105-110.(2004)

Ohtani N, Ohtani H, Nakayama T, Naganuma H, Sato E, Imai T, Nagura H, Yoshie O. Infiltration of CD8+ T cells containing RANTES/CCL5+ cytoplasmic granules in actively inflammatory lesions of human chronic gastritis. Lab Invest. Mar;84(3):368-375.(2004)

Takao-Rikitsu E, Mochida S, Inoue E, Deguchi-Tawarada M, Inoue M, Ohtsuka T, Takai Y. Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release. J Cell Biol. Jan 19;164(2):301-311.(2004)

Deguchi-Tawarada M, Inoue E, Takao-Rikitsu E, Inoue M, Ohtsuka T, Takai Y. CAST2: Identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST. Genes Cells. Jan;9(1):15-23.(2004)

2003年
Yamada A, Irie K, Deguchi-Tawarada M, Ohtsuka T, Takai Y. Nectin-dependent localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of pyramidal cells in the CA3 area of the mouse hippocampus. Genes Cells. Dec;8(12):985-994.(2003)

Shingai T, Ikeda W, Kakunaga S, Morimoto K, Takekuni K, Itoh S, Satoh K, Takeuchi M, Imai T, Monden M, Takai Y. Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem. Sep 12;278(37):35421-35427.(2003)

Ikeda W, Kakunaga S, Itoh S, Shingai T, Takekuni K, Satoh K, Inoue Y, Hamaguchi A, Morimoto K, Takeuchi M, Imai T, Takai Y. Tage4/nectin-like molecule-5 heterophilically trans-interacts with cell adhesion molecule nectin-3 and enhances cell migration. J Biol Chem. Jul 25;278(30):28167-28172.(2003)

Asano A, Asano K, Sasaki H, Furuse M, Tsukita S. Claudins in Caenorhabditis elegans: Their distribution and barrier function in the epithelium. Curr Biol. Jun 17;13(12):1042-1046.(2003)

Inagaki M, Irie K, Deguchi-Tawarada M, Ikeda W, Ohtsuka T, Takeuchi M, Takai Y. Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus. J Comp Neurol. Jun 9;460(4):514-524.(2003)

Kawabe H, Sakisaka T, Yasumi M, Shingai T, Izumi G, Nagano F, Deguchi-Tawarada M, Takeuchi M, Nakanishi H, Takai Y. A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca(2+)-dependent exocytosis of neurotransmitter. Genes Cells. Jun 1;8(6):537-546.(2003)

Morita K, Sasaki H, Furuse K, Furuse M, Tsukita S, Miyachi Y. Expression of claudin-5 in dermal vascular endothelia. Exp Dermatol. Jun;12(3):289-295.(2003)

Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol. May 12;161(3):653-660.(2003)

Yamada A, Miyazaki T, Lu L-M, Ono M, Ito MR, Terada M, Mori S, Hata K, Nozaki Y, Nakatsuru S, Nakamura Y, Onji M, Nose M. Genetic basis of tissue specificity of vasculitis in MRL/lpr mice. Arthritis Rheum. May 1;48(5):1445-1451.(2003)

Sasaki H, Matsui C, Furuse K, Mimori-Kiyosue Y, Furuse M, Tsukita S. Dynamic behavior of paired claudin strands within apposing plasma membranes. Proc Natl Acad Sci U S A. Apr 1;100(7):3971-3976.(2003)

Yasumi M, Shimizu K, Honda T, Takeuchi M, Takai Y. Role of each immunoglobulin-like loop of nectin for its cell-cell adhesion activity. Biochem Biophys Res Commun. Feb 28;302(1):61-66.(2003)

Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y. Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. J Biol Chem. Feb 21;278(8):5497-5500.(2003)

Asada M, Irie K, Morimoto K, Yamada A, Ikeda W, Takeuchi M, Takai Y. ADIP, a novel afadin- and (alpha)-actinin-binding protein localized at cell-cell adherens junctions. J Biol Chem. Feb 7;278(6):4103-4111.(2003)

Yoneda O, Imai T, Nishimura M, Miyaji M, Mimori T, Okazaki T, Domae N, Fujimoto H, Minami Y, Kono T, Bloom E.T, Umehara H. Membrane-bound form of fractalkine induces IFN- production by NK cells. Eur J Immunol. Jan 1;33(1):53-58.(2003)

Katayama H, Satoh K, Takeuchi M, Deguchi-Tawarada M, Oda Y, Nagasu T. Optimization of in-gel protein digestion system in combination with thin-gel separation and negative staining in 96-well plate format. Rapid Commun Mass Spectrom. 17(10):1071-1078.(2003)

2002年
Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, Yonemura S, Yamagishi H, Keppler D, Tsukita S, Tsukita S. Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet. July;31(3):320-325.(2002)

Nanki T, Imai T, Nagasaka K, Urasaki Y, Nonomura Y, Taniguchi K, Hayashida K, Hasegawa J, Yoshie O, Miyasaka N. Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis. Arthritis Rheum. Nov 1;46(11):2878-2883.(2002)

Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y. CAST: A novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and Munc13-1. J Cell Biol. Aug;158(3):577-590.(2002)

Yonemura S, Matsui T, Tsukita S, Tsukita S. Rho-dependent and -indenpendent activation mechanisms of ezrin/radixin/moesin proteins: An essential role for polyphosphoinositides in vivo. J Cell Sci. Jun 15;115(12):2569-2580.(2002)

Nishimura M, Umehara H, Nakayama T, Yoneda O, Hieshima K, Kakizaki M, Dohmae N, Yoshie O, Imai T. Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin(+)/granzyme B(+) cytotoxic effector lymphocytes that are defined by Cx3CR1 expression. J Immunol. Jun 15;168(12):6173-6180.(2002)

Morita K, Furuse M, Yoshida Y, Itoh M, Sasaki H, Tsukita S, Miyachi Y. Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis. J Investig Dermatol. Jun;118(6):1073-1079.(2002)

Fong A.M, Alam S.M, Imai T, Haribabu B, Patel D.D. CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion. J Biol Chem. May 31;277(22):19418-19423.(2002)

Kamogawa J, Terada M, Mizuki S, Nishihara M, Yamamoto H, Mori S, Abe Y, Morimoto K, Nakatsuru S, Nakamura Y, Nose M. Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains. Arthritis Rheum. Apr;46(4):1067-1074.(2002)

Nagano F, Kawabe H, Nakanishi H, Shinohara M, Deguchi-Tawarada M, Takeuchi M, Sasaki T, Takai Y. Rabconnectin-3, a novel protein that binds both GDP/GTP exchange protein and GTPase-activating protein for Rab3 small G protein family. J Biol Chem. Mar 22;277(12):9629-9632.(2002)

Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Noda T, Kubo A, Tsukita S. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: A lesson from claudin-1-deficient mice. J Cell Biol. Mar 18;156(6):1099-1111.(2002)

Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, Imai T, Takai Y. JEAP, a novel component of tight junctions in exocrine cells. J Biol Chem. Feb 15;277(7):5583-5587.(2002)

Mizoguchi A , Nakanishi H, Kimura K, Matsubara K, Ozaki-Kuroda K, Katata T., Honda T, Kiyohara Y, Heo K, Higashi M, Tsutsumi T, Sonoda S, Ide C, Takai Y. Nectin: An adhesion molecule involved in formation of synapses. J Cell Biol. Feb 4;156(3):555-565.(2002)

Satoh K, Takeuchi M, Oda Y, Deguchi-Tawarada M, Sakamoto Y, Matsubara K, Nagasu T, Takai Y. Identification of activity-regulated proteins in the postsynaptic density fraction. Genes Cells. Feb;7(2):187-197.(2002)

Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S. Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J Biol Chem. Jan 4;277(1):455-461.(2002)

2001年
Kawabe H, Nakanishi H, Asada M, Fukuhara A, Morimoto K, Takeuchi M, Takai Y. Pilt, a Novel Peripheral Membrane Protein at Tight Junctions in Epithelial Cells. J Biol Chem. Dec 21;276(51):48350-48355.(2001)

Itoh M, Sasaki H, Furuse M, Ozaki H, Kita T, Tsukita S. Junctional adhesion molecule (JAM) binds to PAR-3: A possible mechanism for the recruitment of PAR-3 to tight junctions. J Cell Biol. Aug 6;154(3):491-497.(2001)

Ishikawa H, Tamura A, Matsui T, Sasaki H, Hakoshima T, Tsukita S, Tsukita S. Structural conversion between open and closed forms of radixin: Low-angle shadowing electron microscopy. J Mol Biol. Jul 27;310(5):973-978.(2001)

Harrison J.K, Fong A.M, Swain P.A.W, Chen S, Yu Y-RA, Salafranca M.N, Greenleaf W.B, Imai T, Patel D.D. Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. J Biol Chem. Jun 15;276(24):21632-21641.(2001)

Umehara H, Goda S, Imai T, Nagano Y, Minami Y, Tanaka Y, Okazaki T, Bloom E.T, Domae N. Fractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1. Immunol Cell Biol. Jun;79(3):298-302.(2001)

Hamada K, Seto A, Shimizu T, Matsui T, Takai Y, Tsukita S, Tsukita S, Hakoshima T. Crystallization and preliminary crystallographic studies of RhoGDI in complex with the radixin FERM domain. Acta Crystallogr Sect D Biol Crystallogr. Jun;57(6):889-890.(2001)

Tanaka M, Miyoshi J, Ishizaki H, Togawa A, Ohnishi K, Endo K, Matsubara K, Mizoguchi A, Nagano T, Sato M, Sasaki T, Takai Y. Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of the adhesion protein ICAM-2. Acta Crystallogr Sect D Biol Crystallogr. Jun;57(6):891-892.(2001)

Tanaka M, Miyoshi J, Ishizaki H, Togawa A, Ohnishi K, Endo K, Matsubara K, Mizoguchi A, Nagano T, Sato M, Sasaki T, Takai Y. Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction. Mol Biol Cell. May;12(5):1421-30.(2001)

Furuse M, Furuse K, Sasaki H, Tsukita S. Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol. Apr 16;153(2):263-272.(2001)

Patel D.D, Koopmann W, Imai T, Whichard L.P, Yoshie O, Krangel M.S. Chemokines have diverse abilities to form solid phase gradients. Clin Immunol. Apr;99(1):43-52.(2001)

Kawasaki S, Takizawa H, Yoneyama H, Nakayama T, Fujisawa R, Izumizaki M, Imai T, Yoshie O, Homma I, Yamamoto K, Matsushima K. Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice. J Immunol. Feb 1;166(3):2055-2062.(2001)

Hashida H, Takabayashi A, Adachi M, Imai T, Kondo K, Kohno N, Yamaoka Y, Miyake M. The novel monoclonal antibody MH8-4 inhibiting cell motility recognizes integrin alpha 3: inverse of its expression withmetastases in colon cancer. Int J Oncol. Jan;18(1):89-95.(2001)

2000年
Saitou M, Furuse M, Sasaki H, Schulzke J-D, Fromm M, Takano H, Noda T, Tsukita S. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell. Dec;11(12):4131-4142.(2000)

Nose M, Terada M, Nishihara M, Kamogawa J, Miyazaki T, Qu W-M, Mori S, Nakatsuru S. Genome analysis of collagen disease in MRL/lpr mice: Polygenic inheritance resulting in the complex pathological manifestations. Int J Cardiol. Aug 31;75(SUPPL 1):S53-61; discussion S63.(2000)

Mimori-Kiyosue Y, Shiina N, Tsukita S. The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules. Curr Biol. Jul 1;10(14):865-868.(2000)

Qu W-M, Miyazaki T, Terada M, Lu L-M, Nishihara M, Yamada A, Mori S, Nakamura Y, Ogasawara H, Yazawa C, Nakatsuru S, Nose M. Genetic dissection of vasculitis in MRL/lpr lupus mice: A novel susceptibility locus involving the CD72(c) allele. Eur J Immunol. Jul;30(7):2027-2037.(2000)

Ono Y, Nakanishi H, Nishimura M, Kakizaki M, Takahashi K, Miyahara M, Satoh-Horikawa K, Mandai K, Takai Y. Two actions of frabin: Direct activation of Cdc42 and indirect activation of Rac. Oncogene. Jun 22;19(27):3050-3058.(2000)

Yoneda O, Imai T, Goda S, Inoue H, Yamauchi A, Okazaki T, Imai H, Yoshie O, Bloom E.T, Domae N, Umehara H. Fractalkine-mediated endothelial cell injury by NK cells. J Immunol. Apr 15;164(8):4055-4062.(2000)

Imai T. Chemokine expression in insect cells. Methods Mol Biol. 138(23-32):(2000)

Imai T. Cloning of novel chemokines using a signal sequence trap method. Methods Mol Biol. 138(11-21):(2000)

Goda S, Imai T, Yoshie O, Yoneda O, Inoue H, Nagano Y, Okazaki T, Imai H, Bloom E.T, Domae N, Umehara H. CX3C-chemokine, fractalkine-enhanced adhesion of THP-1 cells to endothelial cells through integrin-dependent and -independent mechanisms. J Immunol. 164(8):4313-4320.(2000)

1999年
Kamogawa J, Terada M, Nishihara M, Mizuki S, Mori S, Nakatsuru S, Nakamura Y, Nose M. Susceptibility loci to autoimmune arthritis in MRL/lpr mice. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology. Dec;22(6):487-490.(1999)

Nishihara M, Terada M, Kamogawa J, Ohashi Y, Mori S, Nakatsuru S, Nakamura Y, Nose M. Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice: Additive and hierarchical properties of polygenic inheritance. Arthritis Rheum. Dec;42(12):2616-2623.(1999)

Kubo A, Sasaki H, Yuba-Kubo A, Tsukita S, Shiina N. Centriolar satellites: Molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis. J Cell Biol. Nov 29;147(5):969-979.(1999)

Hiiragi T, Sasaki H, Nagafuchi A, Sabe H, Shen S.C, Matsuki M, Yamanishi K, Tsukita S. Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells. J Biol Chem. Nov 26;274(48):34148-34254.(1999)

Furuse M, Sasaki H, Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol. Nov 15;147(4):891-903.(1999)

Nakatsuru S, Terada M, Nishihara M, Kamogawa J, Miyazaki T, Qu W-M, Morimoto K, Yazawa C, Ogasawara H, Abe Y, Fukui K, Ichien G, Ito MR, Mori S, Nakamura Y, Nose M. Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice. Pathol Int. Nov;49(11):974-982.(1999)

Morita K, Sasaki H, Furuse M, Tsukita S. Endothelial claudin: Claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol. Oct 4;147(1):185-194.(1999)

Sonoda N, Furuse M, Sasaki H, Yonemura S, Katahira J, Horiguchi Y, Tsukita S. Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. J Cell Biol. Oct 4;147(1):195-204.(1999)

Kubota K, Furuse M, Sasaki H, Sonoda N, Fujita K, Nagafuchi A, Tsukita S. Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. Curr Biol. Aug 23;9(18):1035-1038.(1999)

Morita K, Sasaki H, Fujimoto K, Furuse M, Tsukita S. Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol. May 3;145(3):579-588.(1999)

総説(英文)

Takai Y, Shimizu K, Ohtsuka T. The roles of cadherins and nectins in interneuronal synapse formation. Curr Opin Neurobiol.13(5):520-6.(2003)

Mimori-Kiyosue Y, Tsukita S. "Search-and-capture" of microtubules through plus-end-binding proteins (+TIPs). J Biochem.134(3):321-6.(2003)

Mimori-Kiyosue Y, Tsukita S. Where is APC going?. J Cell Biol.154(6):1105-9.(2001)

Nose M, Nishihara M, Kamogawa J, Terada M, Nakatsuru S. Genetic basis of autoimmune disease in MRL/lpr mice: dissection of the complex pathological manifestations and their susceptibility loci. Rev Immunogenet.2(1):154-64.(2000)

Nishimura M, Kuboi Y, Muramoto K, Kawano T, Imai T. Chemokines as novel therapeutic targets for inflammatory bowel disease. Ann N Y Acad Sci.1173:350-6.(2009)

Umehara H, Bloom E.T, Okazaki T, Nagano Y, Yoshie O, Imai T. Fractalkine in vascular biology: from basic research to clinical disease. Arterioscler Thromb Vasc Biol.24(1):34-40.(2004)

Umehara H, Bloom E, Okazaki T, Domae N, Imai T. Fractalkine and vascular injury. Trends in Immunology.22(11):602-7.(2001)

Umehara H, Imai T. Role of fractalkine in leukocyte adhesion and migration and in vascular injury. Drug News Perspect.14(8):460-4.(2001)

Yoshie O, Imai T, Nomiyama H. Chemokines in immunity. Adv Immunol.78:57-110.(2001)

総説(和文)

村本賢三. 免疫疾患治療薬の研究・開発戦略 序文. 日本薬理学雑誌.144(4):153.(2014)

村本賢三. 生物学的薬剤から低分子医薬へ. 日薬理誌.142(2):58-62.(2013)

清末優子. 上皮細胞基底側表層における、ラミニン依存性細胞接着による微小管プラス端捕捉. 細胞工学.29(9):916-918.(2010)

清末優子. 微小管プラス端集積因子(+TIPs)の伸長端認識メカニズム. 実験医学3月号「News & Hot Paper Digest」.26(4):532-533.(2008)

井上武, 阿形清和. プラナリアの脳再生の分子機構. 医学の歩み.221(2):193.(2007)

今井俊夫. フラクタルカインの機能と病態への関与. 臨床免疫.45(4):411-417.(2006)

大塚稔久, 井上英二. 神経細胞の極性形成を司るSADキナーゼが神経伝達物質の放出を制御する. 細胞工学.25(7):776-777.(2006)

清末優子. 微小管ダイナミクスと配向を制御する分子機構. 実験医学8月号増刊.24(13):43-51.(2006)

清末優子. 微小管プラス端集積因子 (+TIPs). 蛋白質核酸酵素増刊.51(6):543-550.(2006)

清末優子. 蛍光タンパク質を利用したイメージングを用いた低分子量化合物の作用機序解析. 日本薬学会 薬学研究ビジョン部会 ニュースレター (Pharma VISION NEWS).7:2-8.(2006)

清末優子. 最新 蛍光イメージング活用術 第6回 微小管ダイナミクスのイメージング. バイオテクノロジージャーナル.6(1):98-103.(2006)

山口啓子, 今井俊夫. 免疫細胞の浸潤を制御する接着分子群. Molecular Medicine.42(12):1375-1381.(2005)

久保井良和, 村本賢三, 今井俊夫. ケモカインと炎症性腸疾患. 最新医学.60(10):134-138.(2005)

今井俊夫. フラクタルカインの炎症性疾患における役割. 実験医学.23(20):3072-3077.(2005)

今井俊夫, 西村美由希, 南木敏宏, 梅原久範. フラクタルカインと炎症性疾患. 日本臨床免疫学会会誌.28(3):131-139.(2005)

大塚稔久. Special review 神経プレシナプスアクティブゾーンの構造とその分子基盤. 細胞工学.24(1):66-71.(2005)

梅原久範, 今井俊夫, 堂前尚親 . フラクタルカインと血管障害-基礎研究から臨床病態へ-. 炎症と免疫.12(6):735-742.(2004)

佐々木博之, 松井千幸. イメージングで解き明かす生命機能 イメージングが明らかにしたタイトジャンクションの機能. 実験医学.22(12):1762-3.(2004)

清末優子. イメージングで解き明かす生命機能 微小管プラス端集積因子(+TIPs). 実験医学.22(15):2224-5.(2004)

西村美由希, 今井俊夫. Fractalkine. 炎症と免疫.11(4):435-442.(2003)

真貝竜史, 池田わたる, 今井俊夫, 高井義美 . がんの浸潤・転移における細胞間接着分子ネクチンの役割と作用機構. がん分子標的治療.1(2):16-23.(2003)

梅原久範, 西村美由希, 今井俊夫. ケモカイン・ケモカインレセプターをめぐって リンパ球と血管内皮細胞との相互作用におけるフラクタルカインの関与. 臨床免疫.40(4):371-8.(2003)

今井俊夫, 西村美由希. 新しいサイトカイン・ケモカイン Fractalkine. 炎症と免疫.11(4):435-42.(2003)

清末優子, 月田承一郎. 生きた細胞における微小管プラス端集積因子のイメージング. 実験医学.21(2):265-71.(2003)

今井俊夫, 西村美由希. 薬物ターゲットとしてのケモカイン受容体. ファルマシア.37(4):302-6.(2001)

梅原久範, 今井俊夫, 堂前尚親 . フラクタルカインの基礎と臨床. 臨床免疫.35(3):353-9.(2001)

今井俊夫, 梅原久範 . フラクタルカインによる細胞遊走機構. 免疫・Immunology Frontier.11(1):30-5.(2001)

清末優子. 実験講座 生細胞のイメージング-タイムラプス画像処理とデコンボリューション演算-. 生体の科学.52(12):158-63.(2001)

佐々木博之, 古瀬京子. 高圧凍結法とフリーズフラクチャーレプリカ法. 電子顕微鏡.36(2):102-4.(2001)

今井俊夫. 細胞接着、細胞浸潤とケモカイン. 細胞工学.19(5):717-22.(2000)

清末優子, 月田承一郎. 微小管伸長端局在タンパク質と細胞極性. 細胞工学.19(12):1774-80.(2000)

書籍

今井俊夫. サイトカインのすべて (完全改訂版) 臨床免疫・アレルギー科 第57巻 特別増刊号. CX3CL1/フラクタルカイン. 483-490 (矢田純一 ・ 宮坂信之) 東京. 科学評論社. 2012

井上英二. 創薬・タンパク質研究のためのプロテオミクス解析 バイオマーカー・標的探索,作用機序解析の研究戦略と実践マニュアル. 実験医学別冊 アルツハイマー病治療薬開発をめざしたγ−セクレターゼ基質のプロテオミクス解析. 191-196 (小田吉哉 ・ 長野光司 ・ 小田吉哉 ・ 長野光司) 東京. 羊土社. 2010

清末優子, 米村重信. 細胞・培地活用ハンドブック. 4章, 形態変化、細胞運動、細胞極性 5章, 細胞骨格研究. 40-5 (秋山徹 ・ 河府和義 ・ 秋山徹 ・ 河府和義) 東京. 羊土社. 2008

清末優子, 大和隆志. 阻害剤活用ハンドブック. 細胞骨格・細胞分裂阻害剤. 352-383 (秋山徹 ・ 河府和義 ・ 秋山徹 ・ 河府和義) 東京. 羊土社. 2006

今井俊夫. 血管内皮細胞研究フロンティア. 細胞浸潤における免疫細胞と血管内皮細胞の相互作用. 69-82 (丸山征郎 ・ 丸山征郎) 東京. メディカルレビュー社. 2004

今井俊夫. サイトカイン・ケモカインのすべて. CX3CR/XCR (fractalkine/neurotactin,lymphotactin). 459-470 (笠倉新平 ・ 松島綱治 ・ 笠倉新平 ・ 松島綱治) 東京. 日本医学館. 2004

今井俊夫. 別冊・医学のあゆみ サイトカイン state of arts. フラクタルカインの生物学的意義. 190-1934 (宮坂信之 ・ 宮島篤 ・ 宮坂信之 ・ 宮島篤) 東京. 医歯薬出版. 2004

清末優子, 月田承一郎. わかる実験医学シリーズ 細胞骨格・運動がわかる その制御機構とシグナル伝達ネットワーク. 微小管のダイナミクス制御 微小管プラス端集積因子(+TIPs). 63-72 (三木裕明 ・ 三木裕明) 東京. 羊土社. 2004

今井俊夫. 別冊・医学のあゆみ 7回膜貫通型受容体研究の新展開. ケモカイン受容体. 90-95 (佐藤公道 ・ 赤池昭紀 ・ 佐藤公道 ・ 赤池昭紀) 東京. 医歯薬出版. 2001

今井俊夫. ケモカインハンドブック 細胞工学別冊. CX3CR1. 215-219 (義江修 ・ 野見山尚之 ・ 宮坂昌之 ・ 義江修 ・ 野見山尚之 ・ 宮坂昌之) 東京. 秀潤社. 2000

今井俊夫. ケモカインハンドブック 細胞工学別冊. CCR4. 185-188 (義江修 ・ 野見山尚之 ・ 宮坂昌之 ・ 義江修 ・ 野見山尚之 ・ 宮坂昌之) 東京. 秀潤社. 2000

今井俊夫. ケモカインハンドブック 細胞工学別冊. fractalkine. 142-145 (義江修 ・ 野見山尚之 ・ 宮坂昌之 ・ 義江修 ・ 野見山尚之 ・ 宮坂昌之) 東京. 秀潤社. 2000

今井俊夫. ケモカインハンドブック 細胞工学別冊. MDC. 117-120 (義江修 ・ 野見山尚之 ・ 宮坂昌之 ・ 義江修 ・ 野見山尚之 ・ 宮坂昌之) 東京. 秀潤社. 2000

今井俊夫. ケモカインハンドブック 細胞工学別冊. TARC. 114-116 (義江修 ・ 野見山尚之 ・ 宮坂昌之 ・ 義江修 ・ 野見山尚之 ・ 宮坂昌之) 東京. 秀潤社. 2000

小宮透. ポストシークエンスのゲノム科学 2 ゲノム機能. 第2章 「in situ ハイブリダイゼーションによる発現地図」. (松原謙一 ・ 松原謙一) 東京. 中山書店. 2000

竹内勝一, 高井義美. シリーズ・バイオフィジックスII 4 生体膜のダイナミクス. 第3章 「シナプスの膜裏打ち構造と情報伝達」. (八田一郎 ・ 村田昌之 ・ 八田一郎 ・ 村田昌之) 東京. 共立出版. 2000

溝口明, 清原義幹, 木村一志, 松原佳穂, 西岡秀夫. 組織細胞化学2000. 「1ナノメートル金粒子・銀増感免疫電顕法の理論と応用」. (日本組織細胞化学会 ・ 日本組織細胞化学会) 東京. 学際企画. 2000

研究業績